Contrave vs Ozempic Comparison For Weight Loss

A question mark: Why Am I Not Losing Weight In A Calorie Deficit?

When it comes to weight loss, the journey is never a one-size-fits-all process. Each of us has our own unique struggles, experiences, and wins to celebrate. As someone who’s been on this journey myself, I understand the highs and lows, the moments of triumph, and the times when it feels like the scale just won’t budge. In the pursuit of a healthier weight, many people look towards weight loss medications to give that much-needed boost. We see that today, more than ever, weight loss medications such as Ozempic and Mounjaro are gaining popularity. I’ve written about both of these drugs lately, and recently, I was asked my opinion on Contrave vs Ozempic. So, let’s take a look at how they compare.

As always, before undertaking any kind of weight loss or lifestyle change, it is always best to speak to a medical professional or registered dietician who is best suited to give personalised advice on your individual health needs and health issues. This blog post has been researched to the best of my ability, and the information posted is accurate at the time of publication. With things like this, there are always new developments and advice. It is always best to double-check that any information is accurate and up to date before taking any action.

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What is Contrave?

Before we can make any comparisons, it’s important to establish the basics of what we are looking at. Contrave is a prescription weight loss medication that combines two active ingredients: bupropion and naltrexone. Bupropion is commonly used to treat depression and to help people quit smoking, while naltrexone is often prescribed to manage alcohol and opioid dependence. When these two drugs are combined, they work together to reduce appetite and control food cravings, making it easier for people to stick to a reduced-calorie diet.

Contrave works by targeting the central nervous system, where it helps regulate mood and appetite. This makes it especially useful for those of us who struggle with emotional eating or food cravings. The idea is to reduce the desire to eat, particularly when it’s not driven by hunger but by emotional triggers.

Close up of a person eating a plate of colourful salad

I think it’s important to state that Contrave is not a miracle cure. As much as we would all love to take a medication and instantly shed the weight, I think we can all agree that’s not realistic. Contrave works in relation to a reduced calorie intake. Taking these drugs can make it easier to stick to a lower calorie diet as it helps regulate mood and appetite, BUT without diet changes, it will have little impact.

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What is Ozempic?

Ozempic, on the other hand, is a newer medication that belongs to a class of drugs known as GLP-1 receptor agonists. These medications mimic a hormone in your body called GLP-1, which plays a crucial role in blood sugar control and appetite regulation. Originally approved for the treatment of type-2 diabetes, Ozempic has gained popularity for its ability to promote significant weight loss in people who do not have diabetes as well. You’ve likely heard of Ozempic through news and media channels, as well as its use amongst popular celebrities. Although it is still very early days, it seems to be making a positive impact on those trying to lose weight. 

Ozempic works by slowing down the emptying of your stomach, which makes you feel full longer after eating. It also helps to reduce the amount of food you eat by controlling your appetite. As an injectable medication, it’s administered once a week, which might be a consideration for those who prefer fewer doses or have trouble remembering to take daily medications.

Again, Ozempic, as fabulous as it appears, isn’t a miracle cure and like all medications, it isn’t suitable for everyone.

A card that reads DIET Did I Eat That

Contrave vs Ozempic: The Key Differences

Now that we have a basic understanding of both medications let’s look into a more detailed comparison of Contrave vs Ozempic. Each medication has its own unique benefits and considerations, so it’s essential to weigh these factors carefully.

How They Work

Contrave combines two medications that target the brain’s appetite and reward centres, helping reduce food cravings and emotional eating. It’s particularly beneficial for people who struggle with these issues. Ozempic, as a GLP-1 receptor agonist, works by mimicking a natural hormone that helps control blood sugar levels and appetite. This dual action not only aids in weight loss but also offers benefits for blood sugar control, making it a popular choice for individuals with type-2 diabetes or prediabetes.

Administration and Dosing

Contrave is taken orally, usually as two pills a day. It’s easy to incorporate into your daily routine, but you need to remember to take it consistently. You will see little benefit to taking this medication sporadically. Ozempic, in contrast, is an injectable medication that is taken once a week. For some, the idea of injecting themselves might be daunting, but others may appreciate the convenience of not having to take a daily pill. Again, this is something that needs consideration. 

Pink background with pills - contrave vs ozempic

Efficiency in Weight Loss

As I have already mentioned, these drugs are fairly new to the mass market. Although both Contrave and Ozempic have been shown in clinical trials to help people lose weight, the degree of weight loss can vary on an individual basis. Some users of Ozempic have reported losing up to 15% of their body weight, whereas, with Contrave, the average weight loss tends to be around 5-10% of body weight. However, individual results can vary, and factors such as diet, exercise, and adherence to the medication regimen play a crucial role in how much weight you each individual will lose.

Side Effects and Safety

As with any medication, both Contrave and Ozempic come with potential side effects, and these should always be explored before making any decisions. For Contrave, the most common side effects include nausea, constipation, headache, dry mouth, and insomnia. In some rare cases, more serious side effects like seizures or suicidal thoughts have been reported. It’s crucial to discuss your medical history with your healthcare provider to ensure Contrave is safe for you, especially if you have a history of depression or seizures. 

Ozempic’s side effects often include nausea, vomiting, diarrhoea, and abdominal pain. Most of these symptoms tend to improve over time as your body adjusts to the medication. However, there are also more serious risks, such as the potential for pancreatitis or gallbladder problems, as well as a rare but serious side effect related to the thyroid. Given these risks, it’s essential to consult with your healthcare provider to determine if Ozempic is suitable for you.

Woman standing showing weight loss. Why some people say why slimming world is bad

It’s important to note these drugs are prescription only, and there is very good reason for that. As helpful as they may be in achieving weight loss goals, they are not suitable for everybody. These drugs should only be taken under the guidance and advice of a professional. Due to the popularity of these drugs and subsequent stock issues, there has been an alarming increase in Black Market supply. Although these are often cheaper and easier to get hold of, there is a reason! Please only ever source prescription drugs from professionals.

Impact on Blood Sugar and Cardiovascular Health

One of the standout benefits of Ozempic is its positive effect on blood sugar control, which makes it particularly appealing for those with type-2 diabetes or prediabetes. Additionally, some studies have suggested that Ozempic may offer cardiovascular benefits, potentially reducing the risk of heart disease in certain patients. Unfortunately, Contrave does not have these effects on blood sugar or cardiovascular health, making it a less suitable option for those looking to manage these conditions alongside weight loss.

Lifestyle Considerations

When considering Contrave vs Ozempic, it’s also important to think about your lifestyle and how each medication might fit into it. Contrave, with its twice-daily pill, requires more frequent attention, while Ozempic’s once-weekly injection might be more convenient for those with a busy schedule. However, the injection aspect of Ozempic could be a barrier for some people, for example, those who struggle with needles or find the thought of injecting themselves at home.

Syringe on yellow background Contrave vs Ozempic

As mentioned already, neither of these medications is a miracle cure alone. Both medications work best when combined with lifestyle modifications, such as a reduced-calorie diet, increased physical activity, and behavioural changes. Neither is a magic bullet, but rather tools to help you achieve and maintain a healthy weight. You still have to be willing to make adjustments and changes in order to see results.

Which is the Best Option for You?

Deciding between Contrave vs Ozempic is a personal choice that should be made in consultation with your healthcare provider. It’s essential to consider your medical history and weight-related health problems alongside your personal preferences when making this decision. 

Current and previous health conditions need to be taken into consideration as, for some people, these medications will be unsuitable. As much as these medications seem like ‘wonder’ tools, they certainly shouldn’t be a first-line treatment. It is always best to try and lose weight without the intervention of medication as a first choice. Weight loss drugs would only usually be considered in patients who are over a particular weight or have a weight-related condition. If you have exhausted weight loss on your own already, then speaking with a healthcare professional is your best next step.

Contrave vs Ozempic – Making an Informed Decision

Choosing the right weight loss medication can feel overwhelming, especially when there are so many factors to consider. By comparing Contrave vs Ozempic, you can get a clearer understanding of the options, their benefits, as well as their potential downsides. Remember, there’s no one-size-fits-all solution, and the best choice is the one that aligns with your health needs, lifestyle, and personal preferences. What works for one person won’t necessarily work for the next – this journey is individual, and that’s okay!

As you continue on your weight loss journey, keep in mind that medications like Contrave and Ozempic are tools to assist you in achieving your goals. They work best when combined with healthy lifestyle changes, such as a balanced diet, regular physical activity, and mindfulness around emotional eating. Always consult your healthcare provider before starting any new medication, and continue to reach out for support when you need it. 

If you are on a weight loss journey and want further support and company, then join my free Facebook Group here. Oh, and if you have found this website and articles useful and you’d like to know how you can say thank you, then I am always appreciative of receiving a virtual coffee here.


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Love as always!

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We see that today, more than ever, weight loss medications such as Ozempic and Mounjaro are gaining popularity. I've written about both of these drugs lately, and recently, I was asked my opinion on Contrave vs Ozempic. So, let's take a look at how they compare.

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